Control of low-threshold exocytosis by T-type calcium channels
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چکیده
منابع مشابه
How do T-type calcium channels control low-threshold exocytosis?
Low-voltage-activated T-type calcium channels act as a major pathway for calcium entry near the resting membrane potential in a wide range of neuronal cell types. Several reports have uncovered an unrecognized feature of T-type channels in the control of vesicular neurotransmitter and hormone release, a process so far thought to be mediated exclusively by high-voltage-activated calcium channels...
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Ca(2+) channel subtypes expressed by dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc) were studied using whole cell patch-clamp recordings and blockers selective for different channel types (L, N, and P/Q). Nimodipine (Nim, 2 microM), omega-conotoxin GVIA (Ctx, 1 microM), or omega-agatoxin IVA (Atx, 50 nM) blocked 27, 36, and 37% of peak whole cell Ca(2+) channel current, r...
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Low voltage-activated T-type calcium channels were originally cloned in the 1990s and much research has since focused on identifying the physiological roles of these channels in health and disease states. T-type calcium channels are expressed widely throughout the brain and peripheral tissues, and thus have been proposed as therapeutic targets for a variety of diseases such as epilepsy, insomni...
متن کاملMolecular physiology of low-voltage-activated t-type calcium channels.
T-type Ca2+ channels were originally called low-voltage-activated (LVA) channels because they can be activated by small depolarizations of the plasma membrane. In many neurons Ca2+ influx through LVA channels triggers low-threshold spikes, which in turn triggers a burst of action potentials mediated by Na+ channels. Burst firing is thought to play an important role in the synchronized activity ...
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The ␣ 1E clone has been put forward as a possible candidate for T-type current because it possesses some of the salient features, including low activation voltage, rapid inactivation, and similar or greater whole-cell current amplitude in Ca 2ϩ compared to Ba 2ϩ (Soong et al., 1993). Nevertheless, major discrepancies exist, the main Summary one being that the single channel conductance reported...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Biomembranes
سال: 2013
ISSN: 0005-2736
DOI: 10.1016/j.bbamem.2012.07.031